::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

FORMULATION DEVELOPMENT AND EVALUATION OF MICROSPHERES CONTAINING QUERCETIN EXTRACTED FROM Phoenix sylvestris ROOTS

AUTHORS:

Shakeeb Akhtar Nehal Ahmad*, Dr. Rakesh Kumar Jat, Dr. Rashid Akhtar

ABSTRACT:

Phoenix sylvestris is generally known as Indian date and is native to India. It is traditionally important and known for its nutritional values throughout the world. It is a rich source of carbohydrate, phenols, amino acids, flavonoids, tannins, alkaloids, terpenoids, dietary fibers, essential vitamins and minerals. In the present study roots of Phoenix sylvestris was extracted by Soxhlet extraction method and the quercetin was isolated from the extract by preparative TLC method. Isolated compounds were characterized by spectroscopic techniques like Mass, IR, NMR, etc. Pharmacological investigation includes anti-cancer effect of methanolic extract of root. Isolated quercetin was used as drug to formulate microspheres. The microspheres were prepared by solvent evaporation method using Eudragit LR, 100 as polymer. Different batches (F1, F2, F3, F4, F5 and F6) were prepared with different concentration of polymer (Eudragit). The fabricated microspheres were subjected for different evaluation Parameters. Flow properties such as angle of repose, bulk density, car’s index, Hausner’sratio and it were found that the microsphere shows the good follow properties. Particle size analysis was performed and it shows that increase in polymer concentration increases the particle size. All formulations were subjected for in vitro dissolution study and it was observed that the formulation F6 shows the highest release (93.79%). The release kinetic study has shown that drug release from microspheres follows the Higuchi model as the drug release occurs by diffusion. After performing Stability study for three month of the selected formulation shows no any changes in physical properties as well as in release pattern. Key words: Microspheres, Quercetin, Eudragit, Phoenix sylvestris