::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

THE PREVALENCE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN TYPE II DIABETES MELLITUS PATIENTS IN LAHORE

AUTHORS:

Muhammad Waqas, Muhammad Asad, Dr Salar Ahmad

ABSTRACT:

Introduction: Nonalcoholic fatty liver disease (NAFLD) is diagnosed when >5% hepatic macrovesicular steatosis identified either by histology or imaging in absence of alcohol intake. NAFLD has been regarded as a hepatic manifestation of metabolic syndrome and has been found to be associated with obesity, diabetes mellitus type 2 (T2DM). The aim of this study was to evaluate the frequency of NAFLD in diabetic patients of Northern Pakistan and assess the determining factors. Methods: A cross-sectional, observational study was conducted in Punjab Ranjers Teaching Hospital, Lahore for duration of six months from 1st November 2019 to 30st April 2020. Consecutive, non-probability sampling technique was adopted. All patients of age 30 years or above, of both genders, known cases of T2DM for at least one year, and strictly non-alcoholic presenting in the outpatient department were included. Their demographic, clinical, and biochemical profile was recorded. Data was entered and analyzed using SPSS for Windows version 20.0. Results: The study was completed by 145 participants. There were 67 (46.2%) males and 78 (53.8%) females. The mean age of the participants was 57.3 ± 12.5 years (range: 30-78 years). The mean duration of diabetes was 8.8 ± 6.2 years (range: 2-18 years). Mean BMI was 30 ± 5.5, and HbA1c was 7.9 ± 2.1 (range: 7.3-8.8). Conclusion: Type – 2 diabetic patients with metabolic syndrome having raised BMI, serum cholesterol and triglycerides are more prone to NAFLD. Currently T2DM patient are not routinely screened for NAFLD. Keywords: Diabetes mellitus (DM), Fatty liver, Hepatic steatosis, NAFLD