::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ANALGESIC EFFICACY OF BUPIVACAINE ALONE AND IN COMBINATION WITH TRAMADOL

AUTHORS:

Dr Sahrish Saleem Abbas, Dr Bushra Ghaffar, Dr Wajeeha Naveed

ABSTRACT:

Objective: The aim of this research work was to assess the analgesic effectiveness as well as tolerability of bupivacaine in combination with tramadol and its comparison with the bupivacaine alone. Methodology: This randomized research work was carried out on 200 pediatric patients who were experiencing inguinal hernia repair under GA (General Anesthesia) at Fatima memorial hospital Lahore. We assessed the post-surgical pain at one, two, three, six, twelve and 24 hours and we also evaluated the analgesic needs for ibuprofen and paracetamol of the patients. Results: Total 190 patients got admission for 24 hours for assessment, 4 patients got discharge because their parents refused to get admission. Median intraoperative VAS (Visual Analog Scale) score was 10 in Group-1, obtaining the combined two drugs versus 12 in the patients Group-2 obtaining only bupivacaine (P= 0.020). We found no disparity in scores of pain and requirement of analgesia 12 hours after surgical intervention. Distribution of intraoperative scores of Visual Analog Scale stated that a huge amount of the patients was present with Visual Analog Scale scores higher than 30 after surgery in the patients taking the combined drugs as compared to the bupivacaine alone. Conclusion: The combine utilization of bupivacaine and tramadol infiltration with the ilioinguinal blockades is highly effective as compared to the group of bupivacaine alone and it has the ability to produce fast block’s onset and it also stays for much long duration. The results of this research work recommend this method for the repair of groin hernia to decrease the post-surgical pain. Keywords: Anesthesia, Intraoperative, Hernia, Groin, Visual Analog Scale, Bupivacaine, Tramadol, Intervention, Infiltration.