Dr Muhammad Tanseer Sibtain Raza, Dr Jevaria Tariq, Dr Adil Muhammad
Objective: The purpose of this research work was to investigate the possible relationship of levels of hemoglobin and hepcidin with the statuses of iron and inflammation in the patients of Stage-4 CKD (Chronic Kidney Diseases) present with anemia. Methodology: This transverse research work was carried out at DHQ Hospital Narowal, from January 2019 to June 2020. All the patients were suffering from Stage-4 of CKD with anemia. Measurement of serum biochemical factors of the patients as levels of hepcidin, ferritin, interleukin-6, high sensitivity CRP (C - reactive protein) and iron was carried out with the utilization of standard procedures. We established statistical correlations with the use of Pearson’s correlation coefficient and regression analysis. Results: 30 patients were the participants of this research work in which 37.50% (n: 10) were male patients and 20 (62.50%) were female patients. The average age of the patients was 55.680 ± 14.30 years. We found a significant inverse association between levels of hemoglobin and hepcidin (P<0.050). We discovered a significant relationship between level of serum hepcidin with status of iron, inflammatory & nutritional markers like ferritin, iron binding capacity, levels of albumin and interleukin-6 (P<0.050). Conclusion: There is negative association of hepcidin with the level of hemoglobin in the Stage-4 CKD patients with adequate stores of iron, which can be much efficient for the development of anemia in these patients. Keywords: Anemia, Hepcidin, Chronic Kidney Diseases, Inverse, Coefficient, Regression, Serum, Biochemical, Hemoglobin, Inflammation.