::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

SURGICALLY TREATED EARLY STAGE CERVICAL CANCER –ADJUVANT TREATMENT AND PROGNOSTIC FACTORS

AUTHORS:

Dr Ayesha Zafar, Dr Shahwaza Ajmal, Dr Anam Nazir

ABSTRACT:

Invasive cervical cancer is considered a preventable disease because it has a long pre-invasive condition. If it is detected in the early stages, that is, up to stage IIA1, the disease can be treated with a good survival rate. Aim: To identify the prognostic factors in surgically treated early stage cervical cancer. To study if preoperative findings could accurately predict presence of poor prognostic factors such as nodal Status. To evaluate these histological prognostic factors in deciding the further management of patient with adjuvant treatment. Place and Duration: In the Obstetric and Gynecology department Unit-II of Nishtar Hospital Multan for one-year duration from May 2019 to May 2020. Methods: This is a prospective study of prognostic factors and complementary treatment in 60 cases of early cervical cancer, which are treated surgically to assess histological prognostic factors and decide on the next treatment of the adjuvant patient (radical hysterectomy with pelvic node sediment). Histopathological results were evaluated to determine the prognosis. Results: Involvement of lymph nodes in 25% of cases and invasion of lymph space was observed in 15%. Parametrium was 16.6%. There were 3 patients with a positive margin and 65% of patients had moderate tumor differentiation. The maximum number of nodes in stage IB2 was positive. The size of the tumor larger than 4 cm is an important determinant of the prognosis and has a definite effect on the metastasis to the lymph nodes and other missing factors of histological prognosis. Conclusion: Adjuvant therapy applies to patients with moderate to high prognosis Keywords: cervical cancer, surgical treatment, risk factors.