::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

IMPORTANCE OF GLUCOSE TO INSULIN RATIO (G/R) IN NON-OBESE AND OBESE PATIENTS WITH POLY CYSTIC OVARIAN SYNDROME

AUTHORS:

Dr Anam Nazir, Dr Shahwaza Ajmal, Dr Ayesha Zafar

ABSTRACT:

Polycystic ovary syndrome is a common endocrine disorder in women of childbearing age. This syndrome has a family predisposition. The main problem is the hypothalamic-pituitary axis leading to an increase in the LH / FSH ratio. Insulin resistance and the resulting hyperinsulinemia are common symptoms that lead to altered steroid hormone metabolism and other symptoms of the syndrome. Aim: This study was conducted on sixty women with PCOS, half obese and half non-obese, taken from OPD gynecology and obstetrics department. Place and Duration: In the Gynecology and Obstetrics department of Jinnah Hospital Lahore for one-year duration from May 2019 to May 2020. Methods: They were diagnosed on the basis of an interview, and clinical examination increased the LH / FSH ratio. Forty women, half obese and half non-obese, were taken for control. Fasting glucose and insulin levels were determined and the ratio (GIR) was calculated. Both cases and the control group received 75 g of glucose in 200 ml of water. Two hours after the glucose load, glucose and insulin levels were re-measured and the ratio of glucose to insulin was calculated. Fasting glucose was not significantly high in both obese and non-obese groups. Results and Conclusion: However, significantly higher insulin levels were observed especially in the obese group. Thus, the GIR index decreased (assumed to be 4.5) in 33% non-obese and 60% obese. After being loaded with glucose. Glucose levels were not significantly elevated, but marked hyperinsulinemia was observed in obese subjects. The GIR decreased and was below the cut-off of 4.5 in 80% of non-obese and 86.6% obese cases. These are patients who need insulin sensitizers. Key words: obesity, polycystic ovary syndrome, hypothalamic-pituitary axis