::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ANALYSIS OF DRUG-INDUCED LIVER INJURY BY AMOXICILLIN WITH THE COMPARISON OF CLAVULANATE

AUTHORS:

Dr. Sadia Ishaq, Dr. Abdul Rehman, Dr. Farhat Jabeen

ABSTRACT:

Introduction: Drug-induced liver injury (DILI) is an important differential diagnosis in patients with abnormal liver tests and normal hepatobiliary imaging. Of all known liver diseases, the diagnosis of DILI is probably one of the most difficult one to be established. Objectives of the study: The main objective of the study is to find the drug induced liver injury in hepatic patients with special reference to Amoxicillin with the comparison of Clavulanate. Methodology of the study: This cross-sectional study was conducted at BHU Dhori, District Sargodha, during March 2019 to December 2019. For this purpose we select the 50 patients who was suffering from chronic hepatic injury due to the excessive use of drugs especially Amoxicillin and Clavulanate. Results: We analyzed 50 cases matched to controls. Twenty Seven cases were exposed to amoxicillin (adjusted OR 1.69, 95% CI 0.72-3.98) and 23 cases to co-amoxiclav (adjusted OR 3.00, 95% CI 1.76-5.40). Conclusion: It is concluded that compared to amoxicillin alone, amoxicillin +clavulanic acid doubles the risk of serious acute liver injury, in agreement with most studies on DILI.