::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

DIAGNOSTIC ACCURATENESS OF SPLEEN DIAMETER/ PLATELET COUNT RATIO FOR RECOGNITION OF ESOPHAGEAL VARICES IN PATIENTS WITH LIVER CIRRHOSIS TAKING ENDOSCOPY AS GOLD STANDARD

AUTHORS:

Dr. Amna Babar, Dr. Fatima Babar, Dr Farhad

ABSTRACT:

Introduction: Esophageal varices are common in patients with cirrhosis of the liver, and their frequency is estimated at 50%. Presumably, various non-invasive radiographic and ultrasound (US) indicators have been demonstrated, including spleen size, portal vein velocity (PVV), portal vein diameter, hepatic impedance indices, spleen impedance indices, and esophageal multi-slice computed tomography results. esophageal varices worsening Aim: To determine the diagnostic accuracy of the platelet count to spleen diameter in the detection of esophageal varices in patients with liver cirrhosis. Study design: A cross-sectional study Place and Duration: In the Medicine department of Mayo Hospital Lahore for one-year duration from March 2019 to March 2020. Results: In our study, 23 (10.70%) were 12-30 years old, 93 (43.25%) 31-50 years old, and 99 (46.05%) 51-80 years old, mean ± standard deviation was calculated as 46.93 ± 13.22 years, 124 (57.67%) are women, and 91 (42.33%) are men, the incidence of esophageal varices in patients with cirrhosis (in endoscopic examination) reveals 131 (60.93%), while 84 (39.07%) were not reported with this morbidity and the diagnostic accuracy of the platelet count to spleen diameter in the detection of esophageal varices in patients with cirrhosis, we recorded 124 (57.67%) true positive, 4 (1.86%) false positive, 80 (37.21%) true negative and 7 (3.26%) false negative, the sensitivity, specificity, positive predictive value, negative predictive value and the accuracy factor were calculated to be 96 respectively. 95%, 95.24%, 96.88%, 91.95% and 94.88%. Conclusion: We found that the diagnostic accuracy of the platelet count to spleen diameter ratio in detecting esophageal varices in patients with cirrhosis is significantly higher, and we have recommended its use in our clinical practice as part of the diagnosis of patients with cirrhosis in order to reduce the financial and sanitary burden endoscopy department and medical costs related to screening of electric vehicles. Keywords: liver cirrhosis, esophageal varices, platelet count to spleen diameter ratio.