::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A COMPARATIVE STUDY OF METOCLOPRAMIDE ALONE AND IN MIXTURE WITH DEXAMETHASONE FOR DETERRENCE OF POST-OPERATIVE NAUSEA AND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY

AUTHORS:

Dr Muhammad Azeem Afzal, Dr. Fatima Babar, Dr. Amna Babar

ABSTRACT:

Aim: To compare the efficacy of intravenous administration of metoclopramide alone and in combination with dexamethasone in the prevention of postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy. Study design: randomized, single-blind, intervention study. Place and Duration of Study: This study was conducted at the Surgical department of Allied Hospital Faisalabad for one-year duration from March 2019 to March 2020. Patients and methods: After obtaining the approval of the hospital's ethics committee, the study was conducted on 100 patients who were randomly divided into two groups A and B, 50 people in each group. They all belonged to the age of 25-40. Randomization was performed using the envelope randomization method. Patients received metoclopramide 10 mg alone or metoclopramide 5 mg and dexamethasone 4 mg intravenously 30 minutes prior to induction of anesthesia. All patients were subjected to general anesthesia with endotracheal intubation with sodium thiopentone and succinylcholine and was maintained with isoflurane and N2O with O2 in both groups. PONV was assessed after surgery. Results: Patients in group B who received metoclopramide in combination with dexamethasone had significantly less nausea and vomiting in the first 24 hours after surgery compared to patients in group A who received only metoclopramide. Conclusion: In this study, a single dose of 5 mg metoclopramide and 4 mg dexamethasone produced a better antiemetic effect after laparoscopic cholecystectomy than 10 mg metoclopramide alone. Keywords: PONV, dexamethasone, metoclopramide, laparoscopic cholecystectomy.