::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

FREQUENCY OF ULCERATIVE COLITIS (UC) AND CROHN’S DISEASE IN THYROID DISORDERS IN PATIENTS ATTENDING TERTIARY CARE HOSPITAL

AUTHORS:

Dr Jawad Ahmad Khan, Dr Nasrullah Ayoubi, Dr. Ammar Farooq

ABSTRACT:

Aim: In patients with ulcerative colitis (UC) and Crohn's disease (CD), an increase in thyroid dysfunction has been reported compared to the normal people. This study was held to assess the thyroid disease prevalence in the inflammatory bowel disease patients group. Study Design: A Retrospective study. Place and Duration: This study was conducted in the Medicine Department of Lady Reading Hospital, Peshawar for one year duration from April 2019 to March 2020. Methods: 155 patients were included (120 UC, 35 CDs) and 63 healthy control subjects. Patients with free T3 (FT3), T4 (FT4), anti-TPO serum and TSH were evaluated retrospectively and with the group of control were compared. These patients were examined using nuclear imaging (scintigraphy) and thyroid ultrasound. Results: 42.9 ± 12.4 years was the average age of patients with IBD (76 women). The control group consisted of 42 women and 40.9 ± 12.1 years was the average age. In 18 patients (9.5%, 8 women, 6 men) out of 155patients with inflammatory bowel disease, thyroid disease was diagnosed. The thyroid disorders frequency was higher in IBD group than in the group of control (18/155 vs. 1/63, p = 0.042). There was no substantial dissimilarity in the frequency of thyroid orders in cases of CD and UC (5/40 vs 13/115, p = 0.912). In 4 (2.7%) IBD patients, Hashimoto's thyroiditis was noted. Conclusion: According to many studies issued in the literature, we have noted greater fraction of thyroid disease in inflammatory bowel disease patients. Key words: Thyroid disease, Crohn's disease, Ulcerative colitis.