Dr Ruqaya Bashir, Dr Ahmad Kamal, Dr Raina Amin.
After cardiac surgery, post-operative cognitive decline is a well known and common complication. POCD is characterized by the impaired functions of memory and intellectual ability of a person linked to health care resources. The focus of the investigators has been upon the potential factor like inflammation owing to a surgical procedure that is involved in the POCD pathogenesis. A randomized controlled study was carried out on prophylactic dexamethasone where it was used to attenuate the inflammatory response and its impacts upon lowering the risk for the POCD. The duration of this trial was from January 2016 to January 2017 and total 170 patients were added, out of which 161 were added in the analysis. Patients were randomized and intravenous bolus of 0.1 mg/kg dexamethasone was given 10 hours before surgery. In comparison to the placebo group, the dexamethasone group showed significant POCD reduction and systematic inflammation. Post operative S100β levels were also found lower in the dexamethasone group.