Dr Malik Muhammad Uzair Khan, Dr Ifrah Naeem, Dr Aleena Naeem, Dr Ayeza Nadeem, Dr Muhammad Junaid Aslam
Stroke is a major contributing factor to the increase in morbidity and mortality rate in people with sickle cell disease (SCD). Stroke in more professional terms is known as a cerebrovascular accident. There are two main types of stroke, ischemic stroke and hemorrhagic stroke. Stroke can cause physical as well as cognitive deficits. Despite the high number of stroke cases in SCD patients, it still remains a poorly understood condition. Small or large vessel disease, chronic inflammation, altered cerebral autoregulation, hemolysis, and anemia (sickle cell disease) are risk factors for stroke. In this paper, we have reviewed the epidemiology of ischemic and hemorrhagic stroke in adults with sickle cell disease. We will also discuss the approach for its management (acute treatment and secondary prevention) and general risk factors.