::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

COMPARISON OF THE EFFICACY OF INTRA-ARTICULAR DEXAMETHASONE, DEXMEDETOMIDINE AND ROPIVACAINE IN POST-OPERATIVE PAIN CONTROL IN PATIENTS UNDERGOING ARTHROSCOPIC SURGERIES OF THE KNEE JOINT

AUTHORS:

Dr. Muhammad Aqeel Zafar, Dr. Ghayyur Khalil, Dr. Zuhaib Ahmad

ABSTRACT:

Objective: An effective analgesia helps decrease the surgical stress response and expedites recovery. The aim of our study was to compare the effectiveness of three drugs namely dexamethasone, dexmedetomidine and ropivacaine in controlling post-op pain. Methodology: Prospective double blinded study of 75 individuals undergoing arthroscopic knee restorative operation from July 2018 to June 2019, at Services Hospital Lahore, Pakistan randomly divided into three groups. Group 1 received only ropivacaine, Group 2 received ropivacaine and dexmedetomidine and the third group received dexamethasone with ropivacaine. The amount of analgesics administered in the first post-surgical day as well as the time till the first post-op administration was recorded. Results: The time till first postoperative request of analgesia was longest in Group III (1370.56 ± 198.26 min) compared with Group 2 (436.4 ± 56. min) and Group 1 (52.49 ± 64.71 min) (p = 0.04). The mean post-op analgesia given during the first post-operative day was least in group 3 (40.4 ± 29.85 mg) when compared group 1 (241.27 ± 58.96 mg) and group 2 (157.91 ± 53.7 mg) (p 0.03). Conclusion: Dexamethasone 317 μl/kg(at one point is written 317 and at other 310) is just as safe and reaction-free, but offers improved post-surgical pain control as compared to dexmedetomidine. KEY WORDS: Dexamethasone, Knee, Arthroscopy, Dexmedetomidine, Ropivacaine.