::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

LIVER FUNCTION TESTS DERANGEMENT IN CRITICALLY ILL CHILDREN

AUTHORS:

Dr. Muhammad Ehtisham Tariq Sadiq, Dr. Muhammad Sadiq, Dr. Jansher Khan Gochi

ABSTRACT:

Aim and purpose: To determine the frequency of liver dysfunction in critically ill patients admitted to the intensive care unit. Patients and Methods: This is a prospective, descriptive observational study conducted in the intensive care unit of the Pediatric department of Ayub Teaching Hospital Abbottabad. The study included all patients aged 1 month to 12 years. Patients with pre-existing chronic liver disease were excluded from the study. The pre-designed proforma form was completed with parental consent. Proforma included an appropriate history, clinical signs, laboratory results, interventions (if required), and outcome. All patients were adequately treated and their liver function tests monitored. All data entered into SPSS-version 16 and the results were analyzed as a percentage. Results: A total of 100 patients were enrolled in the study. Among them were 57% men and 43% women. Most of the patients, 75 (75%), were under 5 years of age and the mean age was 34.25 months. In 47% of patient’s liver dysfunction was diagnosed, the most common causes of which were sepsis (46.8%), followed by tuberculosis (15%), intestinal fever (12.7%), central nervous system infections (6.38%), bronchopneumonia (10.6%), acute watery diarrhea (4.2%) and others (2.1%). Conclusion: Of the critically ill patients, 47% had early liver dysfunction, and sepsis was the most common cause. As liver dysfunction has wide pathophysiological implications, it is considered a major risk factor in sick children in intensive care.