::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

RHEUMATIC HEART DISEASE OUTCOME BETWEEN MITRAL VALVE REGURGITATION AND MITRAL VALVE PROLAPSE

AUTHORS:

Samim Azizi, Humayoun Amini, Sayed Farhad Rasuli, Yasin Faiz Mohammad, Naqibullah Nasar, Najim Azizi

ABSTRACT:

Objectives: To assess the most common valvular diseases presented in patients with RHD and associated complications. Methodology: a cross sectional observational study was conducted from November 2019 to March 2020 at Lady Reading Hospital, Peshawar Pakistan for a duration of six months. All patients over the age of 18 years with diagnosed rheumatic heart disease who presented in the out patients’ department were included in the study using consecutive sampling technique. Patients below the age of 15 years who had congenital malformations were excluded. All valvular disorders were observed and the frequency of each was noted. Associated complications were also noted. Data was collected on a preformed proforma. Analysis was performed using SPSS version 24. Results: The mean age (SD) of patients was 36 (5.6) years with 67 (29.6%) male and 159 (70.3%) female patients. Mitral valve lesions were seen in 197 (86.7%) patients. 100 (44.2%) had mitral regurgitation and 97 (42.9%) had mitral stenosis. The frequency of Mitral valve lesions was higher in patients between the age group 26-35 years and 36-45 years. 19 (8.4%) patients had aortic lesions. Both mitral and aortic valve lesions were seen in 16 (7.0%) patients. The most common complication was pulmonary hypertension seen in 118 (52.21%) patients. Conclusion: RHD and concomitant valvular disorders are a major concern in Pakistan. Further large scale cohorts should be conducted to evaluate the major risk factors associated with the severity of the valvular diseases. Keywords: Aortic stenosis, mitral regurgitation, rheumatic heart disease, valvular disorder