::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

VALUATION OF LEVELS OF SERUM FERRITIN IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA

AUTHORS:

Dr Tooba Marriam, Dr Muhammad Usama Arshad, Dr Ragda Imran

ABSTRACT:

Background: Acute lymphoblastic leukemia (ALL) is the most common malignant neoplasm of childhood. Although an increase in serum ferritin is known with many forms of malignant tumors, the pattern of elevation in different stages of ALL has not yet been elucidated. Objectives: To evaluate serum ferritin, uric acid and LDH levels in patients with acute lymphoblastic leukemia. Materials and Methods: This is a case-control study conducted in the Medicine department of Mayo Hospital Lahore in Collaboration with Oncology department for one-year duration from May 2019 to May 2020. A total of 160 people was enrolled in the study, including 80 ALL patients as cases; and sexually matched, 80 healthy individuals as controls. All test results were statistically analyzed using the Social Sciences Statistical Package (SPSS) version 20.0. Results: The study involved 160 people, 80 patients with ALL, 42 of whom (52.5%) were men, and 38 (47.5%) were women. The mean age in the group of patients was 17.6 ± 5.6 years. The control group consisted of 80 healthy people who were matched in terms of age (17.8 ± 12.1) and sex (52.5% men, 47.5% women) to the case group. Among patients with ALL, statistically significant positive correlations were found between the number of blasts: serum ferritin (r = 0.735, p <0.0001), uric acid (r = 0.618, p <0.0001) and LDH (r = 0.570, p <0.0001). Conclusions: ALL was associated with elevated serum ferritin levels. Serum ferritin was significantly correlated with different disease stages and showed a positive linear correlation with the concentration of uric acid, LDH and serum blasts, therefore the determination of serum ferritin could be used as prognostic markers of ALL. Key words: serum ferritin, acute lymphoblastic leukemia, blood.