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A COMPARATIVE STUDY ON THE PROPERTIES OF ANTISICKLING AGENTS

Dr. Maimona Rafiq, Dr. Muhammad Rizwan Saeed, Dr. Hafiz Rana Kamran Ijaz

Objective: The most common antisickling medicines are the chemical agents of thiocyanate, hydroxyurea & tellurite & in recent times, these are the centre of research for many research works. The AP (anti-sickling properties) of these three drugs was interrogated & contrasted with one another in this research work. Methodology: Human abnormal or sickle blood kept alive with the help of the drugs in artificial environment outside the living organism at concentrations linked to the prescribed amount utilized by the patients in the organism or in vivo. The function of the haemoglobin & particular features of the method of sickling were calculated with the use of the standard procedures utilized in selecting the antisickling means. Results: All these medicines prevented the sickling of abnormal blood without oxygen & the creation of the sickle cells in only one dose & in a way which is depending upon the time. The drugs of thiocyanate, hydroxyurea & tellurite prevented the process of sickling twenty mM, forty mM & fifty µM respectively. Thiocyanate & hydroxyurea enhance the life span of the sickle RBC as displayed in the important reduction in lysis of erythrocytes with the release of haemoglobin & fragility of osmotic while tellurite has the ability to increase the various factors of the blood. The increase in the delay of the duration of polymerization of HbS (haemoglobin S) is the result of these three drugs. Thiocyanate & hydroxyurea are the cause of high value of ratio of solubility & oxygen affinity of haemoglobin S. Conclusion: The outcome of this research work shows that these 3 mentioned drugs have the ability of antisickling in an artificial environment outside the living organism with thiocyanate as the most effective one. Keywords: Organism, Antisickling, Solubility, Anomalies, Haemoglobin, Auto haemolysis, Potassium

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