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CHANGES IN MCV IN PREGNANCY AND THALASSAEMIA AT MAYO HOSPITAL LAHORE

Dr. Fayyaz Hussain Jarwar, Dr. Muhammad Waqar Inaam, Dr. Ahmad Nawaz

Objective: The aim of this research is to observe the positive and negative predictive value, specificity and sensitivity of the MCV (Mean Corpuscular Volume) in minor beta-thalassemia screening among expecting females presented at Mayo hospital Lahore. Methodology: This research was carried out at Victoria Hospital Bahawalpur from January 2017 to December 2017. We interviewed pregnant females through a pre-designed questionnaire about the Gestational Age (GA) and Demographic Profiles. MCV was ≤ 70 fl as assessed on the first antenatal visit. Level of HbA2 was assessed through Hemoglobin (Hb) Electrophoresis in order to identify the minor beta-thalassemia carriers. Outcomes were analyzed on SPSS software. Results: Minor Beta-thalassemia can best be assessed through MCV as among one hundred patients MCV was ≤ 70 fl in fifty-three percent of the females. Specificity and sensitivity were respectively 30% and 79% in the positive MCV assessment (under 70 fl) as observed in the beta-thalassemia screening. Both negative and positive predictive values were respectively reported as 56%. Conclusions: It is reported in the research that specificity and sensitivity were respectively 30% and 79.9% in the positive MCV assessment (under 70 fl) as observed in the beta-thalassemia screening. Both negative and positive predictive values were respectively reported as 56%. Minor Beta-thalassemia can best be assessed through MCV as among one hundred patients MCV was ≤ 70 fl in fifty-three percent of the females. Thalassemia can be prevented through regular MCV screening. All young women can better be assessed through MCV in future in order to determine sub-fertility in the pregnant females. Keywords: Mean Corpuscular Volume (MCV), Beta Thalassemia and Antenatal Screening

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