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A COMPREHENSIVE STUDY ON ANTIOXIDANTS AS A BIOMARKER OF CARDIOVASCULAR RISK IN YOUNG PEOPLE

Dr. Muhammad Asad Abdullah, Dr. Noor-us-Syyam Sumra, Dr. Khalid Nawaz

Introduction: An increasing number of studies focus on the role of reactive oxygen species (ROS) in the pathogenesis of premature ageing as well as of numerous civilization diseases, such as cardiovascular diseases. It has been suggested that higher antioxidant potential can protect the organism against undesirable ROS activity and thus prevent disease incidence. Aims and objectives: The basic aim of the study is to analyze the level of antioxidants as a biomarker of cardiovascular risk in young people. Material and methods: This cross sectional study was conducted at Bahawal Victoria hospital, Bahawalpur during 2018. There were 50 participants who selected for this study from both genders. In the course of myocardial ischemia and reperfusion the increased concentration of free radicals may also cause an increase in antioxidant enzymes activities. In order to exclude the possibility of acute ischemia-reperfusion reactions. Results: We collected all the demographic data of patients. Duration of disease positively correlated with HIP-1α (r = 0.677, P <0.001) but negatively correlated with VEGF (r = −0.486, P < 0.001); VEGF positively correlated with each of pyruvate (r = 0.316, P <0.047) and HIF-1α (r = 0.374, P <0.018), and, OSI positively correlated with TPX (r = 0.969, P <0.001), but, negatively correlated with TAC (r = −0.469, P <0.002). Conclusion: It is concluded that TAC, assayed with either the FRAS or the DPPH methods, does not differ between men with and without CVD when additional confounders are taken into consideration.

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