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ANALYSIS OF EFFECT OF PROBIOTIC YOGURT CONSUMPTION ON OXIDATIVE STRESS AND INFLAMMATORY FACTORS IN CHILDREN

Dr. Syed Muhammad Amad Imtiaz, Dr. Hafiz Muhammad Saad Zafar, Dr. Syed Muhammad Ali Raza

Introduction: Oxidative stress which is referred to imbalance between prooxidants and antioxidants is very common in petrochemical workers. Exposure to petrochemical contaminants such as benzene, toluene, ethylbenzene, and xylenes and diesel exhaust particulate leads to increased production of reactive oxygen species (ROS) and free radicals, which in turn would result in increased oxidative stress. Aims and objectives: The basic aim of the study was to analyze the effect of probiotic yogurt consumption on oxidative stress and inflammatory factors in children. Material and methods: This study was conducted at Children Hospital Complex & ICH, Multan during Nov 2017 to May 2018. For this purpose of study we select the children of age 2 years to 10 years who consume the yogurt on daily basis. We get all the data related to dietary intake of selected participants. During the run-in period after stratification for body mass index (BMI) and age, participants were requested to record their dietary intakes for three nonconsecutive days. Results: There was no significant relationship among age, weight, calorie, and nutrients intake in control and supplement groups. the blood levels of SOD, GPX and serum levels of TAC significantly increased, whereas the serum level of TNF-α, MMP2, MMP9, MDA significantly decreased in the supplement group compared to the control group (p<0.05). There were no significant differences between the two groups in the serum levels of other biochemical factors such as hs-CRP, IL6, and TNF-α after intense physical activity (p>0.05). Conclusion: It is concluded that consumption of probiotic yogurt or multispecies probiotic capsule had beneficial effects on biomarkers of oxidative stress in children.

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