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A CROSS-SECTIONAL STUDY TO EXAMINE ANTIOXIDANT STATUS OF WOMEN BY APPLYING FOUR DISSIMILAR CONTRACEPTION METHODS

1Dr. Aqsa Akram, 2Dr. Muhammad Qasim, 3Dr. Ayesha Hussain

Objective: This research is designed to examine the antioxidant status of women through the application of four dissimilar methods of contraception. Methodology: We selected a sample of (60) non-pregnant women whose age ranged between (16 - 45) years and applied four diverse methods as, oral contraceptive pills, Norplant, injectable and intra-uterine devices (IUD) who were attending Nishter Hospital Multan. For the control group, we selected fifty-eight women, ranged from (16 – 45), seemed healthy who were not observing any contraceptive technique. Researchers determined the body mass index (BMI) of all research participants either who subjects or controls group were. By using standard spectrophotometric methods, we determine the serum levels of ascorbic acid, tocopherol, bilirubin, uric acid, creatinine, malondialdehyde, albumin total protein. We took an estimated value of Progesterone with the help of the chemiluminescence method and for the determination of selenium, we applied atomic absorption spectrophotometry (AAS). Results: Researchers acquired a significant value of BMI in women by using oral contraceptive pills (OCP) in comparison with the control group (P<0.05) while we noted it insignificant (P>0.05) among injectable, intra-uterine device (IUD), and Norplant users. The women who were on OCP reported with mean serum ascorbic acid (P<0.01), total protein (P<0.01), albumin (P<0.05), tocopherol (P<0.05), selenium (P<0.01), uric acid (P<0.05), which were significantly lower when we took an insight of comparison if it with the control group. But in terms of users of other contraceptive methods, it was insignificant (P>0.05). Moreover, researchers did not find any apparent one to one association between antioxidants and progesterone among women who were on IUD, OCP, Norplant and injectable. Conclusion: The methods like injectable, IUD and Norplant presented no effect, whereas, oral contraceptive pills displayed a significant declining effect on the status of antioxidants. Conclusively, scholars recommend a routine monitoring of the antioxidant status for the subjects who are undergoing through different methods of contraceptive, especially who are on OCP. Keywords: Norplant and injectable, Chemiluminescence, Contraception, Antioxidants, cardiovascular disease

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