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SPERM DNA FRAGMENTATION, AGE AND MALE INFERTILITY

Afrim Zeqiraj1 , Zafer Gashi2 , Shkelzen Elezaj3 , Sheqibe Beadini1 , Nexhbedin Beadini1 , Hesat Aliu1 , Sadi Bexheti4 , Zehra Hajrulai-Musliu 5 , Agim Shabani6

The aging process in the male reproductive system may include changes in testicular tissue, sperm production, and the like. Unlike females, males do not experience a substantial, rapid change (which occurs over a few months) until they grow older, instead of menopausal women, changes in males occur gradually (andropause). Purpose of the work: It is determined how age affects the appearance of male infertility. For the purpose of our study we analyzed: Sperm DNA fragmentation and oxidative stress. Materials and Methods: There were analyzed 257 patients, 169 patients in the working group and 88 patients in the control group. Patients received for analysis were all from the Republic of Kosovo. The sampling period was 2014/2018. All analyses were performed at Biolab Zafi, Laboratory in Peja. Results: The average DNA fragmentation values in sperm and oxidative stress were higher in the study group compared to that of the control. All differences were of significant statistical significance P<0.05. Conclusion: We can conclude that the results of DNA fragmentation in the sperm are encouraging and can be used for diagnostic purposes in determining male infertility. We recommend that an assessment of oxidative stress levels in infertile male ejaculation should be part of routine work in clinical andrology clinics to assist clinicians in determining infertility status and in setting optimal medical treatment. Key words: Sperm DNA fragmentation, IVF/ICSI, SCD.

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