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TITLE:

PRADER-WILLI SYNDROME REVIEW AND ANALYSIS: SYSTEMATIC REVIEW IN LITERATURE

AUTHORS:

Ahmed Alsharhan1*, Lujain Abdu2 , Rawan Alsafh3 , Dania Alibrahim3 , Abdullah Alraqi4 , Asalh Saeedi2 , Hatun Shualuwalah2 , Ahmed Alanazi4 , Ghadeer Surrati3 , Duaa Alahmadi3

ABSTRACT:

This review is aiming to review and analysis the Prader -Willi Syndrome. The present review was conducted by searching in Medline, Embase, Web of Science, Science Direct, BMJ journal and Google Scholar for, researches, review articles and reports, published over the past years. Books published on the Prader-Willi Syndrome. If several studies had similar findings, we randomly selected one or two to avoid repetitive results. Based on findings and results this review found. The studies provided evidence that absolute TEE, REE, SEE, and AEE are lower in individuals with PWS than in age-, sex-, and body mass index–matched individuals without the syndrome. Alterations in lean body mass and lower physical activity amounts appear to be responsible for the lower energy expenditure in PWS rather than metabolic differences. Regardless of the underlying mechanism for lower TEE, the estimation of energy requirements with the use of equations derived for the general population would result in weight gain in individuals with PWS. The determination of energy requirements for weight management in individuals with PWS requires a more comprehensive understanding of energy metabolism. Future studies should aim to comprehensively profile all specific components of energy expenditure in individuals with PWS with the use of appropriately matched controls and gold standard methods to measure energy metabolism and body composition Keywords: Prader-Willi syndrome, energy metabolism, resting energy expenditure, activity energy expenditure

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