Abdullah Kahlil Albalawi *, Azam Abdulrahem Althqafi, Khadijah Jadah Asiri, Ghada Ali Algadda, Fatimah Hussain Abu Qurain, Omar Ahmed Alturki, Noora Ahmed Al Yazidi, Reem Fareed Aldeijy, Ohoud Ahmed Haddadi, Mohammed Hassan Alomrani
Sickle cell disease is a serious haematological disorder associated with significant morbidity and mortality. Therefore, it has been a disease of concern of many healthcare researchers; and despite the various advances in discovering the pathogenesis of the disease, many basic scientific processes are still not understood. Vitamin D association with sickle cell disease was one of the topics of recent interest. Vitamin D deficiency is known to be very common among patients with sickle cell anemia. Although the exact relationship between them remains elusive, some researchers postulated that the immunomodulatory role of vitamin D plays a role in reduction of the associated complications and the severity of sickle cell anemia symptoms. Over the last few decades, the association between vitamin D and sickle cell disease became clearer, and the understanding of this association led to a notable improvement in management of sickle cell disease and reducing its associated morbidity, complications, and mortality. This article will discuss the association between vitamin D deficiency and sickle cell anaemia and review how treating this deficiency state helped to improve the outcome of sickle cell disease. Keywords: Anaemia, vitamin D deficiency, sickle cell, sickle cell disease.