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THROMBOLYSIS IN ACUTE ISCHEMIC STROKE

Faisal Abdulrahman Althobaiti, Arwa Faisal Shaheen, Dalal Ayedh Al-Harbi, Abdulaziz Saud Alroqi, Khalid Sulaiman Alhunaiti, Ahmad Mahmmod Balosh, Danya Bakhsh, Mohammed Ahmed Alshammari, Nasser Mohammed Alamer, Abdullah Ayman Aman, Feras Abd-Almoneem Saati, Sabah Ayedh Alotaibi

Introduction: A stroke can happen due to ischemia, or an embolic occlusion, or a hemorrhage, and is one of the major causes of devastating, prolonged neurologic morbidity and functional disability. Moreover, it is the leading cause of mortality globally. The current Stroke recommended protocols in management requires swift assessment and admission, alongside the administration of thrombolysis for acute ischemic stroke (AIS), prompt management by the specialists in a stroke unit, and early usage of aspirin in AIS and proper physiological monitoring. Aim of work: In this review, we will discuss window period for effective management of ischemic stroke, and the methods of thrombolysis. Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1985, through February 2017. The following search terms were used: stroke, acute ischemic attack, cerebrovascular accident, window period, intravenous thrombolysis, arterial thrombolysis, mechanical thrombolysis Conclusions: Thrombolysis is at the leading edge of modern management of AIS, with significant evidence of its efficacy before the 4.5 h of the beginning of symptoms. Intravenous alteplase is the solely recommended and approved thrombolytic agent currently. nevertheless, the frequency of treated individuals is still somewhat low due to a number of burdens and failures in the optimal accomplishment of the treatment. Endovascular therapy in acute ischemic stroke has become a promising alternative for patients who are ineligible for intravenous thrombolysis or have failed in recanalyzing the occluded artery. Key words: stroke, management if stroke, thrombolysis, alteplase

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