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RISK FACTORS FOR MDR TB IN VULNERABLE PATIENTS

Dr Salik Ahmed Cheema, Dr Mohammad Mustafa, Dr Muhammad Abdul Rehman

Objective: The objective of our study was to determine the frequency of risk factors for MDR TB in vulnerable groups. Methodology: 80 patients of MDR-TB who presented to the Out Patient Department (OPD), were recruited into six vulnerable groups namely; Prisoners, Immigrants, Pregnant Women, Drug Addicts, Diabetics and Children . A detailed questionnaire containing a list of the possible risk factors for MDR TB in each group was administered to the relevant participant. Information regarding socioeconomic status, comorbidity, patient compliance, drug availability (free or purchased), and their contacts was obtained and analyzed through SPSS Software. Descriptive analysis and cross tabs were used to obtain the results. Results: Of the 80 participants 93.8% had low socioeconomic status, 66.2% had acquired only primary education, 40% had contact history and 30% could not complete DOTS regimen. Crowded living, delayed diagnosis of disease and inadequate nutrition were also found to be significant risk factors for MDR TB. Specific risk factors found in diabetics were lack of lifestyle modifications and irregularity in checking blood sugar levels. For drug abusers, most of whom resorted to oral drugs and half to intravenous, smoking and alcoholism were found to be potential predisposing factors for MDR TB. Conclusion: Our study shows the challenges involved in treating MDR TB and the complications that arise when comorbidities and social and financial restrictions are taken into account. Studies with longer time spans, larger sample size for individual groups and controlled trials can better highlight these aspects in future studies. Key words: MDR-TB. Multi-drug resistant tuberculosis. Factors.

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