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TITLE:

FORTITUDE OF THE PRO-INFLAMMATORY PROFILE OF EXTREMELY OBESE CHILDREN IN LAHORE DIVISION

AUTHORS:

Dr Haneen Zahid, Aiman Ikram, Dr Faiza Batool

ABSTRACT:

Aim: To assess the status of pro-inflammatory markers in children with obesity. Subjects and methods: The study involved 37 children (20 non-obese and 17 obese). Levels of C reactive protein, α-2 macroglobulin (A2M) and hepatoglobin were measured. Anthropometric results are correlated with biochemical parameters. Study Design: A Cross-Sectional Study. Place and Duration: In the Department of Biochemistry, Services Hospital Lahore for one year period from February 2018 to February 2019. Results: The mean CRP in serum, A2M and hepatoglobin were several folds advanced in the obese group than in the group of control (p <0.05). CRP was significantly correlated with body weight (BW), body physique index (BMI) and A2M (p-value <0.05). Conclusion: Childhood obesity is linked with a pro-inflammatory state before the appearance of co-morbidities of metabolic syndrome, whereas haptoglobin, CRP and A2M are the best indicator of inflammation development. Key words: Obese children, CRP, inflammatory profile.

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