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TITLE:

EFFICACY OF THE SOFOSBUVIR AND LEDIPASVIR IN TREATMENT OF CHILDREN SUFFERING FROM INFECTION OF HEPATITIS C VIRUS

AUTHORS:

Dr Muhammad Mubeen Qayyum, Dr Siddique Abbas, Dr Danish Nawaz

ABSTRACT:

Objectives: The aim of this research work is to find out the effectiveness of the oral antivirus (Sofosbuvir/Ledipasvir) in the treatment of the children suffering from hepatitis C virus infection. Methodology: This research work carried out in the Pediatrics department of Shaikh Zayed Medical College and Hospital Rahim Yar Khan from June 2018 to March 2019. All the patients with positive Polymerase Chain Reaction (PCR) of HCV having age from 7 to 18 years were the part of this research work. Background history, clinical assessment and examination of the patients carried out. The genotyping of HCV was also carried out. We gave Sofosbuvir or Ledipasvir to all the patients of this research work on daily basis. We also added the Ribavirin for the patients who were INF-experienced or present with the established liver cirrhosis. We carried out the follow up with the function of liver, function of kidney and Polymerase Chain Reaction (PCR) at twelve week of treatment and then after the 12 week. The Total duration of this treatment was twelve weeks which increased to twenty-four weeks in some patients who were present with established liver cirrhosis. SPSS V.20 was in use for the statistical analysis of the collected information. Results: There were total twenty-two patients with an average age of 12.50 years, 63.60% (n: 14) patients were male and 36.40% (n: 8) patients were females. The most dominant genotype was grnotype-1 (75.0%). We achieved the sustain virological response-12 in 90.90% (n: 20) patients, remaining 9.10% (n: 2) patients were present with partial response of HCV. We found the co-infection of HBV in 5 patients, in the duration of treatment all these patients kept on the Entecavir. All the patients obtained sustain virological response-12 for hepatitis C virus with the reduction in the power of HBV infection. Even the patients with INF-experienced (seven patients, 31.80%) were available as responsive with the sustain virological response-12. There was well toleration to the treatment. Conclusion: Sofosbuvir or ledipasvir has much effectiveness in the treatment of the HCV infection among children and this treatment is well-tolerable.

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