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THE ACCURACY OF THESE TESTS FOR PREDICTING DRIVEN FIBROSIS IN PATIENTS WITH HCV

Dr. Naveed Zafar, Dr. Aziz Ur Rehman, Dr. Samee Ullah Anwar

Aim: The exact arrangement of liver fibrosis becomes the medical requirement to assess anticipation and make results for cases having hepatitis C infection. Non-invasive methods, which depend on standard and minimum effort studies to investigate liver fibrosis, were applied to rise plausibility of medical application in daily repetition; purpose of the research is to evaluate the accuracy of these tests for predicting driven fibrosis in patients with HCV. Materials and Methods: Our current research was conducted at Mayo Hospital Lahore from November 2017 to October 2018. This study is a comfort associate in which 98 HCV patients were followed for 14 weeks throughout antiviral treatment. Overall respondents experienced liver biopsy and through laboratory information the qualities for non-invasive strategies, APRI, FIB-4 and GPR, were determined to evaluate the accuracy of tests related to liver biopsy as well as viral genotypes. Results: The agreement of APRI in conjunction with liver biopsy in advanced fibrosis remained AUROC = 0.68 (CI 96% 0.56-0.78). The GPR technique speaks with an AUROC = 0.58 (CI 96% 0.47-0.75) for cutting edge fibrosis, whereas FIB-4 speaks with an AUROC = 0.68 (CI 96% 0.57-0.81) for cutting edge fibrosis. When considering the three tests used (p = 0.307), no critical distinction was found. In addition, we found only a factual distinction for GPR (p = 0.007) when assessing the tests related to viral genotypes, with better accuracy for genotype 3-4. Conclusion: We discovered the relationship among viral genotypes and driven fibrosis in association of GPR; though, outcomes displayed nothing but poor memory precision for all the files studied in the current population. Keywords: Hepatic fibrosis; Liver biopsy; Hepatitis C.

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