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DETERMINATION OF ASSOCIATION BETWEEN BIO-CHEMICAL STRICTURES OF NUTRITIONAL CONDITION WITH THE SEVERITY OF THE LIVER CIRRHOSIS DUE TO HCV

Dr. Kashif Saeed, Dr. Shahab Rafique, Dr Shajia Shabbir

Objective: This research work carried out to determine the association between different bio-chemical strictures of nutritional condition with the severity of liver cirrhosis due to HCV infection in our institute. Methodology: This was transverse research work on total two hundred and fifty nine patients suffering from liver cirrhosis related to HCV who visited the OPD of Mayo Hospital, Lahore from July 2017 to March 2019. We used the PCR for the confirmation of the HCV status. Ultrasound was used in start to establish the confirmation of cirrhosis whereas CTP score was in use for gauge of the severity of cirrhosis. The bio-chemical parameters for the nutrition condition included the LDL, ferritin, serum albumin, serum cholesterol, creatinine, calcium, sodium, potassium and magnesium. We also recorded the clinical as well as demographic data of the patients. Results: The average age of the patients was 58.730 ± 6.040 years with 57.10% being the male patients. Mean body mass index of the patients was 22.720 ± 1.690 kg/m2. Most of the patients as 47.50% (n: 123) belonged to the group of CTP-A, 25.90% (n: 67) patients were in group of CTP-B & 26.60% (n: 69) patients in the group of CTP-C. There was significant negative associations of the severity of liver cirrhosis with the body mass index, LDL, TG, Hemoglobin level, magnesium, calcium, creatinine and albumin as identifier of malnutrition. When we carried out the analysis of bio-chemical strictures amongst the persons of all groups of cirrhosis, we come to know that there was significant negative association across the similar features in CTP-C group, whereas CTP-A was present with strong association with present parameters. Conclusion: Considering the hindrances of the standard approaches only to evaluate the malnutrition in complication of liver cirrhosis, bio-chemical strictures are valid to support in the diagnosis of the prevailing malnutrition. Keywords: Strictures, hindrances, prevalence, cirrhosis, HCV, methodology, PCR.

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