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COLCHICINE AS A NATURAL TOXICANT AND METHODS OF ITS ANALYSIS

Migachev Alexei Sergeevich, Gegechkori Vladimir Iraklievich, Gorainova Daria Anatolievna, Belova Maria Vladimirovna , Sevan Siuzanna Mukhammedovna, Alieva Milana Niyazi kizi

Colchicine is an indispensable medical alkaloid of the Colchicaceae family. It is still used in the treatment of gout, recurrent illness, Behcet's disease and many other diseases. Despite the centuries-old experience of using this alkaloid by humans, fatal cases of poisoning are still encountered. Materials and methods. The authors analyzed specialized literature in databases and search engines Google Scholar, PubMed, Web of Science, Scopus, eLibrary on the toxicological, pharmacological, technological and clinical significance of colchicine. Results. Pharmacodynamics, clinical signs and pathological changes in case of colchicine poisoning are described based on the data of contemporary literature. In addition, the basic principles of the qualitative and quantitative determination of substances from biological material are illustrated. Keywords: colchicine; Colchicum autumnale; toxicology; poisoning; extraction.

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