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TITLE:

IMPACT OF APELIN-13 ON OSTEOPOROSIS IN THE PATIENTS SUFFERING FROM DIABETES MELLITUS

AUTHORS:

Dr Kainat Sarwar, Dr Sabahat Rafique, Dr Umema Habib

ABSTRACT:

Objective: This research work aimed to examine the association between Apelin-13 level in serum and BMD (Bone Mineral Density) as well as some other factors, and to determine the impact of Apelin-13 on the osteoporosis among patients suffering from T-2DM (Type-2 Diabetes Mellitus). Methodology: There were total 67 persons in this research work. This research work carried out in Endocrinology Department of our institute from March 2015 to September 2019. We recorded the clinical information, age of the patient, sex, weight, height, BMI and duration of the disease for the patients of this research work. The collection of the blood samples carried out for the examination of Apelin-13, PINP (Procollagen Type-I N Propeptide) & crosslinked carboxyterminal telopeptide of Type-1 collagen and we used a dual-energy absorptiometry scanner for X-ray for the testing of the bone mineral density. Results: We divided the patients into 3 groups. There were total nineteen patients in the group of osteoporosis, twenty five patients in the group of osteopenia and thirty two patients in the group of normal. Apelin-13 level in the group of osteoporosis was much lower as compared to the groups of normal & osteopenia. The level in the group of osteopenia was much low as compared to the group of normal. The analysis of correlation displayed that there was a positive correlation between Apelin-13 and BMD & PINP but it was present with negative correlation with the ICTP & age. Conclusion: The findings of this research work showed that there was a strong association between the Apelin-13 and PINP, BMD & ICTP. There is a vital role of Apelin-13 in the prevalence of the osteoporosis among patients suffering from T-2DM. Keywords: T-2DM, BMD, prevalence, osteoporosis, correlation, osteoporosis. Apelin-13.

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