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ANALYSIS OF LEVELS OF ANTIOXIDANTS IN THE BLOOD WITH THE USE OF ROPIVACAINE FOR GENERAL ANESTHESIA

Hifza Fatima, Hajira Zainab, Iqra Asif

The objective of this study was to determine if ropivacaine has any effects on the antioxidant defense system and in lipid peroxidation as Melanodialdehyde (MDA) of spinal fluid. This cross sectional study was conducted in Saadan hospital, Lahore during March 2019 to October 2019. To measure the levels of lipid peroxidation, glutathione (GSH), superoxide dismutase (SOD) and the levels of catalases (CAT), samples were taken from the vein before anesthesia (0 min) and at 5, 15, and 60 min. after anesthesia. The levels of MDA , SOD and GSH slightly increased at 5 min after spinal injection of ropivacaine and this increase continued throughout anesthesia (P<0.001). Catalases levels were decreased at 5 min after anesthesia (P<0.001) and this level not recovered after 60 min of anaesthesia. In conclusion, we found that spinal injection of ropivacaine increased free radical levels in spinal fluid which may be supported antioxidant environment of spinal fluid during anesthesia.

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