ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

ANALYSIS OF PTEROSTILBENE IN INDUCTION OF APOPTOSIS THROUGH DOWN REGULATION OF CASPASE ACTIVATION IN OVARIAN CANCER PATIENTS

Shair Ali Khan, Noor Tariq, Athar Ali Shahbaz

The basic aim of the study is to elucidate the mechanism of action of pterostilbene against ovarian cancer cells. This cross sectional study was conducted at Midcity Hospital, Lahore during January 2019 to July 2019. The 5cc blood was drawn for the analysis of ROS. Reactive oxygen species was determined using fluorescent probe DCF-DA. Pterostilbene-induced ROS generation was measured by DCF-DA. The results showed that pterostilbene-induced ROS generation at 120%, 134% and 157% in 12, 24 and 48 h, respectively. The present study demonstrates for the first time that pterostilbene- induces apoptosis in ovarian cancer cell line, through ROS generation, mitochondrial depolarization, activation of caspase 9 and 3.

FULL TEXT