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STUDIES ON DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS CONTAINING TIZANIDINE

Dr.Patil C C, Yogitha M, Vijapure VK, Jorapur PN, Karajagi S

In the present study, describes the Studies on development and evaluation of sustained release matrix tablets containing tizanidine. Were prepared by wet-granulation method using polymers like Guar gum & Ethyl cellulose in different ratios. Matrix tablet evaluated by different methods for parameters such as hardness,weight, thickness, drug content uniformity. The tablets were evaluated for in vitro release in pH 1.2 and 7.4 phosphate buffer for 12 hours in standard dissolution apparatus. In order to determine the mode of release, the data was subjected to First order, Zero order, and Pappas and Higuchi diffusion model. Uniformity in vitro drug release studies and stability studies Short term stability studies on the promising formulation indicated that, there are no significant changes in drug content. IR spectroscopic indicated that there are no drug- excipients interaction. All the granules of the formulation showed in compliance with Pharmacopoeia Standards. The developed sustain released matrix tablet of Tizanidine drug showed 12 hours of drug release and overcome the disadvantage of conventional tablets. Keywords: Matrix tablet, Tizanidine, Guar gum, Ethyl cellulose.

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