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THE ACCURACY OF THESE TESTS TO PREDICT INDUCED FIBROSIS IN HCV PATIENTS

Dr Nayab Zonish Nawaz, Aftab Arslan, Dr Qurat-ul-Ain

Aim: The exact disposition of hepatic fibrosis becomes the medical necessity to evaluate anticipation and obtain results for cases of hepatitis C infection. Non-invasive methods, based on standard and minimally invasive studies to study hepatic fibrosis, have been applied to increase the plausibility of medical application in daily repetition; the purpose of the research is to assess the accuracy of these tests to predict induced fibrosis in HCV patients. Materials and methods: Our current research was conducted at the Jinnah Hospital in Lahore from January 2018 to November 2019. This study is a comfort study in which 96 HCV-infected patients were followed for 16 weeks throughout the antiviral treatment. Overall, respondents underwent a liver biopsy and, based on laboratory information, the qualities of the non-invasive strategies, APRI, FIB-4 and GPR, were determined to assess the accuracy of liver biopsy tests and viral genotypes. Results: APRI's agreement with liver biopsy in advanced fibrosis remained AUROC = 0.67 (95% CI 0.57-0.75). The GPR technique speaks with an AUROC = 0.59 (95% CI 0.48-0.76) for cutting edge fibrosis, while the FIB-4 speaks with an AUROC = 0.68 (95% CI 0.55-0.82) for cutting edge fibrosis. Considering the three tests used (p = 0.308), no critical distinction was found. In addition, we found only a factual distinction for GPR (p = 0.008) when evaluating tests related to viral genotypes, with a better accuracy for genotype 4-5. Conclusion: We discovered the relationship between viral genotypes and controlled fibrosis in association with GPR; however, the results showed low memory accuracy for all files studied in the current population. Key words: Hepatic fibrosis; Liver biopsy; Hepatitis C.

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