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ROLE OF INFLAMMATION IN OBESITY & DIABETES MELLITUS

Dr Syeda Ijlal Zehra Zaidi, Dr Naghmana Lateef, Dr Farhat Ijaz, Dr Shaheena Naz, Dr Rana Khurram Aftab, Dr Sumera Saghir

Background& Objectives: Obesity which is an alarming medical disorder usually presented with inflammation of low grade is documented to be associated with elevated level of C-reactive protein (CRP), a renowned protein of acute phase produced by the liver. We conducted this study to correlate the likely inflammatory role in obese diabetic and non diabetics. Methods: We measured serum glucose in fasting state of 6-8 hours; serum insulin and levels of CRP in forty obese diabetics with BMI of 35 ± 5 kg/m2 and forty non diabetics obese with BMI of 33 ± 3 kg/m2. Model of HOMA IR was used to assess insulin resistance. Data was presented as mean with standard deviation of every parameter of the current study. P value less than 0.05 was reflected statistically significant. Results: We noted noticeably raised Body mass index BMI, level of C reactive protein fasting blood glucose, insulin resistance amongst the diabetics as compared to controls. Analysis through Pearson’s correlation test exposed significant positive correlation amongst BMI, HOMA-IR and CRP in obese diabetics. Likewise, a less noteworthy relationship also existed between all these parameters in obese non diabetics Conclusion: We concluded that noteworthy association occurs amongst insulin resistance and inflammatory marker CRP in obese diabetics having T2DM. Key Words: Obesity, Inflammation, Diabetes Mellitus, C-reactive protein, Body Mass Index

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