Dr Jaweria Sana, Dr Maryam Mehmood, Dr Masooma Batool
Partner and localizer of BRCA.2 (PALB2) is a chest tumor defenselessness gene that performs a huge feature in DNA mend. This is the first examine assessing the occurrence of PALB2 mutations in early-onset and genetic chest/ovarian tumor patients from Pakistan. Chest most tumors has a massive crash on the overall most tumors burden in Pakistan comprising 60% of all woman malignancies. In Pakistan, monoallelic germline mutations inside the excessive and moderate-penetrance chest tumor vulnerability genes BRCA.1, BRCA.2, TP53, CHEK2, and RAD51C account for approximately 30% of early-onset and genetic chest tumor suggesting that different vulnerability gene(s) may be concerned. Newly diagnosed PALB2 gene, an accomplice and localizer of BRCA.2, acts as a link among BRCA.2 and BRCA.1 and allows DNA repair.