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THERAPEUTIC EFFECT OF DIETARY NITRATE AND ALLICIN IN MODULATING HYPERTENSION

Momina Shahid, Shahnai Basharat, Syed Aamir Gilani, Breera Shahid, Muhammad Mustafa Qamar

There are many causes and factors that lead to hypertension, including a high intake of sodium and alcohol, low consumption of fruits and vegetables, deficiency of some water-soluble vitamins such as B9, B2, and fat-soluble vitamins such as C and D and a sedentary lifestyle. In recent years, therapeutic effect of dietary nitrate and allicin emerged as an essential component for normal physiological as well as pathological functioning to treat hypertension. NO3- being a potent dilator, administrates systemic blood pressure and subsequently delays atherogenesis. Various cardiovascular diseases are associated with its bioactivity including pre-hypertension, hypertension, atherosclerosis, and stroke. Allicin has antibacterial, anti-carcinogenic and antioxidant effect and acts against many microorganisms. It also has angiotensin II–inhibiting and vasodilating effects. Garlic involves two nitric oxide, and hydrogen sulfide signaling pathways that lower BP. It has the ability to enhance arterial inflammation, stiffness, and other cardiovascular indicators. Both components are considered as highly acceptable with the great safety profile as an antihypertensive treatment. Therefore, this article aimed to highlight the important role of nitrate and allicin in modulating hypertension. Keywords: Dietary Nitrate, Allicin, Hypertension, Diastolic Blood Pressure, Systolic Blood Pressure, Cardiovascular Diseases

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