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TITLE:

UNIVARIATE AND MULTIVARIATE REGRESSION ANALYSES OF FACTORS AFFECTING THE CENTRAL CORNEAL THICKNESS (CCT): A SINGLE TERTIARY CENTRE PERSPECTIVE

AUTHORS:

Dr.Fereshteh Kargar Bafrani, Dr.Tannaz Aghaei Badr, Dr. Tafseer zahra, Dr.Abdul Wahab, Faranak Kargar Bafrani

ABSTRACT:

Objective: - To determine the factors influencing CCT such as age, sex, smoking habits, alcoholism, diabetes mellitus, hypertension, obesity, metabolic syndrome, corneal curvature and axial length. Materials and Methods: - This prospective cross-sectional study was undertaken in Isfahan, Iran between July-2018 to Febrauary-2019. The study population consisted of 216 patients aged 18 years and older who presented to our clinic for a routine eye check-up. After a standardized interview with patients, a comprehensive ocular examination which also includes IOP and visual acuity were taken. We then measured Central Corneal Thickness (CCT) and Axial length were measured using Ultrasound Sonomed 300A+ PacScan Plus A-scan. Results: - It was found that on multivariate analysis age, diabetes duration, corneal curvature and IOP were association with CCT (p<0.05). However, on univariate analysis, age, presence and duration of diabetes, elevated fasting blood glucose levels, alcohol abuse, corneal curvature and IOP were associated with CCT. Conclusion: - The patient population in our study have corneal thickness comparable to that of Caucasians. We found that CCT was significantly associated with age, diabetes duration, corneal curvature and intraocular pressure.

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