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COMPARISON OF THE GLYCEMIC CONTROL AND FETO-MATERNAL OUTCOMES IN THE PATIENTS OF GESTATIONAL DIABETES TREATED BY INSULIN VERSUS METFORMIN

Dr Prof Muhammad Ali, Dr Warda Khan, Dr Saima Shams

Objective: The aim of this research work is to compare and assess the glycemic control and feto-maternal results in the patients of gestational diabetes treated insulin and metformin. Methodology: The duration of this research work was from 2016 to 2018 in DHQ Teaching Hospital Dera Ghazi Khan. Total seventy-one person suffering from gestational diabetes mellitus who were included in this research work. We obtained the consent from all the patients. We separated the patients into 2 groups. On the group-A, thirty-two females obtained the oral metformin 500.0 milligram TDS whereas thirty-nine female patients of Group-B obtained insulin 0.80-0.90 mg/kg per day in 2 separated doses intravenously. We followed the patients till term. We evaluated the feto-maternal results in twenty-five patients in every group who remained in this research till end. Results: When we compared both groups, new births from the females of Group-B were present with more weight. An important proportion of babies were delivered after thirty-eight pregnancy weeks from the females of Group-B. Total 2 intra-uterine deaths occurred and there was much high HbA1C level at term in the females of Group-B. There was not significant FBS at complete term and there was high occurrence of the CS (Cesarean Section) because of the feto-maternal imbalance in the females of Group-B (28.0% vs .20%). We also analyzed the results for the glycemic control pre and post treatment showed that there was statistically less FBS in the females of Group-A, while in the females of Group-B, the level of HbA1C and FBS. Conclusion: There were better impacts of metformin on the feto-maternal results and glycemic control as compared to the insulin in the patients of gestational diabetes mellitus. KEYWORDS: Gestation, Delivery, Cesarean Section, Intra-Uterine, Pregnancy, Insulin, Metformin.

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