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FORMULATION AND EVALUATION OF QUINAPRIL Hcl SUSTAINED RELEASE TABLETS

V. Mallikarjun*, V. Rajesh Babu

The work was designed to formulate and evaluate the quinapril Hcl Sustained release tablets which is used for management of Anti hypertensive diseases. Tablets were prepared by wet granulation method with different concentration of HPMCK4, HPMCK100 and guar gum as retard polymer to release the drug for prolonged time. The evaluated studies revealed that weight variation, hardness, friability and drug content test were within pharmacopeial limit. The drug release from formulations F1-F3 was almost 97-99% by 8hrs, F4-F6 was released 98-99% within 10hrs, F7-F9 released 99% of drug by the end of 12hrs.F8 was found to be optimized which released 96.03% of drug over 12hrs and follows zero order kinetics. The drug release was independent of concentration followed higuchi mechanism. Key words: quinapril Hcl, Sustained release tablets, HPMCK4, HPMCK100.

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