ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

TO STUDY THE ROLE OF TRANEXAMIC ACID IN REDUCING MATERNAL MORTALITY AND NEED OF SURGICAL INTERVENTION WITH CLINICALLY DIAGNOSED POSTPARTUM HEMORRHAGE (PPH) IN WOMEN

Dr.Mahe talat, Dr.Maimunah Faruque Malik, Dr Nuzhat kanwal

Background- The percentage of deaths greater than 25% are due to postpartum hemorrhage and to decrease the maternal mortality find out the treatment of PPH is very important. Objective- The objective of this study is to analyze that either tranexamic acid and antifibrinolytic agent reduce the rate of maternal mortality or not with the need of surgical intervention with diagnosed PPH in women and to determine that either tranexamic acid has adverse drug reaction or not. Methodology- This study was conducted in Mayo hospital Lahore. A lot of women were enrolled for this study to diagnosed PPH. All the patients were subdivided into two groups. First group was control group and second group was study group. BRASS-V drape was used to collect the sample and blood and to differentiate them. In this study the main reasons of maternal mortality was diagnosed. For failed medicl management and due to this the need of surgical intervention and PPH was observed. Due to the use of tranexamic acid, side effect of this was also observed. Result-From different perspectives for example parity distribution, delivery type, age and postpartum hemorrhage’ causes both groups were compared. In first group that is control group 744±102ml was the mean loss in blood and in study group 626±113ml due to the use of tranexamic acid, the difference in these group was very significant. In both groups no patients was observed maternal mortality due to the PPH treatment failure. Blood loss can be reduced by tranexamic acid. The need of surgical intervention due to the treatment failure of PPH was also not observed in any patient. Conclusion- From this study it was concluded that blood loss can be reduced by tranexamic acid and due to this maternal mortality in patients can also be reduced by PPH Keywords: Blood loss, tranexamic acid, maternal mortality, postpartum hemorrhage

FULL TEXT