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EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF POLYHERBAL FORMULATION IN CAFETERIA DIET INDUCED HYPERLIPIDEMIC RAT MODEL

Anitha Nandagopal*, Adeeba Husna, Anupama Koneru

The purpose of the present study is to elucidate the antihyperlipidemic activity of the polyherbal formulation of methanolic extract of Moringa olifera leaves, Trachyspermum ammi seeds and Mimosa pudica leaves (MMTM) in cafeteria diet induced hyperlipidemic rats. The rats were given a high fat diet called Cafeteria diet to induce hyperlipidemia for 21 days. The extraction for the polyherbal formulation was done by methanol using Soxhlet apparatus. The phytochemical analysis revealed the presence of flavanoids, steroids, phenols and tannins. The administration of the MMTM formulation resulted in decrease in the body weights of the hyperlipidemic rats when compared with the disease control. Treatment with MMTM 200mg/kg and 400mg/kg significantly decreased TC, TG, LDL and increased HDL levels. The histopathological results also revealed normal hepatocytes in the MMTM treated group. Hence it may be concluded that antihyperlipidemic activity of the MMTM extract may be due to the presence of phytochemical constituents such as flavanoids, steroids, phenolic compounds and tannins. Key words: Cafeteria diet, Trachyspermum ammi, Mimosa pudica, Moringa olifera, Hyperlipidemia.

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