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ANALYSIS OF EPIGENETIC VARIATION BY SMALL MOLECULE COMPOUNDS FOR DIFFERENT NEURODEGENERATIVE DISORDERS

Ammar Zafar, SyedaAiman Zahra Naqvi, Mubbarik Hussain

Epigenetics and epigenomic medicine encompass a new science of brain and behavior that are already providing unique insights into the mechanisms underlying brain development, evolution, neuronal and network plasticity and homeostasis, senescence, the etiology of diverse neurological diseases and neural regenerative processes.The basic aim of the study is to explore the epigenetic variation by small molecule compounds for different neurodegenerative disorders. The accumulation of somatic and genetic mutations which altered the structure and coding information of the DNA are the major cause of neurological disorders. However, our recent understanding of molecular mechanisms of ‘epigenetic’ phenomenon reveals that the modifications of chromatin play a significant role in the development and severity of neurological disorders.Neurodegenerative disorders are among the major difficulties and among the most medical issues that should be with standed by the world, particularly in light of expanding population age. They cause the degeneration and death of nerve cells as they form incurable conditions for treatment.Regardless of that specific set of semantic conventions, it also seems clear that the term neuroepigenetic is emerging due to the discoveries of a wide variety of roles for epigenetic molecular mechanisms in the CNS regarding acquired behaviors, CNS disorders, neural plasticity, neurotoxicity, and drug addiction . Thus, we have the emerging sub discipline now being called neuroepigenetics.

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