::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

RELATIONSHIP BETWEEN HYPOALBUMINEMIA AND INTRADIALYSIS HYPOTENSION IN HEMODIALYSIS PATIENTS

AUTHORS:

Dr Haider Iftikhar, Dr Tooba Qaiser, Dr Shafaq Mussadiq

ABSTRACT:

Background: Hypoalbuminemia is an important risk factor for the development of hypotension during hemodialysis and progressive left ventricular hypertrophy in patients with chronic kidney disease (CKD). Aim: The aim of the study was to evaluate the relationship between serum albumin, intradialysis hypotension (IDH) and cardiac function. Place and Duration: In the Nephrology and Cardiology department of Nishtar Hospital Multan for one-year duration from August 2019 to 2020. Patients and Methods: Forty patients undergoing regular hemodialysis (HD) were enrolled in the study. They were divided into two groups; Group 1: Patients in this group had recurrent attacks of IDH and Group 2: Patients in this group did not develop IDH. Patients were reclassified according to their serum albumin level into two groups; Group A: patients with hypoalbuminemia and group B: patients without hypoalbuminemia. Data collected from each patient included: (1) demographic characteristics (age, gender) and clinical characteristics (changes in blood pressure during the session, ultrafiltration index, cardio-thoracic ratio, duration of dialysis and Kt / V); (2) Blood chemistry (creatinine, urea, hemoglobin, hematocrit value, total proteins, albumin, triglycerides, cholesterol, AST, ALT, Kt / V and fasting blood sugar); and (3) Echocardiographic evaluation of left ventricular geometry. Results: There was a significant negative correlation between serum albumin and Delta BP in HD patients. There were also no significant changes in heart function in the various groups studied. Conclusion: We concluded that there is an association between low serum albumin and intradialysis hypotension and cardiac function in patients with CKD undergoing HD. Recommendations: Regular serum albumin testing is mandatory for all HD patients. Key words: hemodialysis, hypoalbuminemia, risk factor, intradialysis hypotension.