- CODEN : IAJPBB
- issn 2349-7750
TITLE:
EFFICACY OF TOPICAL CALCIPOTRIOL IN THE MANAGEMENT OF CHRONIC PLAQUE PSORIASIS
AUTHORS:
Dr Nazish Anwar, Dr Abdul Raheem, Dr Ayesha Dawood
ABSTRACT:
Introduction Calcipotriol ointment (DAIVONEX) has been shown to be effective in the treatment of chronic plaque psoriasis. Aim: To evaluate the efficacy and safety of calcipotriol ointment (50 µg / g) in the treatment of chronic plaque psoriasis. Patients and Methods: A prospective, non-controlled, open clinical trial of calcipotriol ointment (50μg/g) was conducted in the department of Dermatology, Bahawal Victoria Hospital, Bahawalpur for one-year duration from July 2019 to July 2020. A total of 61 patients (39 male, 22 females, aged 18 to 76 years) with chronic plaque psoriasis were enrolled in an open-label, prospective study. 51 completed the study. Calcipotriol ointment was applied twice daily for up to 6 weeks to the lesion area, after a 2-week washout phase with liquid paraffin. Efficacy, as measured by the Psoriasis Severity Index (PASI), and safety were assessed at 2, 4 and 6 weeks. Results: The reduction in PASI was statistically highly significant at all visits. Mean PASI decreased from 10.47 to 2.18 over 6 weeks (p <0.001). An analysis of the patient evaluation after 6 weeks showed total body clearance in 8% of patients and a marked improvement in 71% of patients. Serum calcium levels remained unchanged. Conclusion: Topical application of 50 µg / g calcipotriol ointment was found to be effective and safe in the treatment of chronic plaque psoriasis. Key words: Calcipotriol (DAIVONEX), psoriasis treatment, PASI
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