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TITLE:

HISTOPATHOLOGICAL SPECTRUM OF LEISHMANIASIS IN PUNJAB

AUTHORS:

Dr Ayesha Dawood, Dr Abdul Raheem, Dr Nazish Anwar

ABSTRACT:

Aim: The aim of the study was to determine the different histological spectrums of cutaneous leishmaniasis and to discover whether there are other useful histological findings in addition to the detection of amastigotes that could assist in the diagnosis. Materials and methods: The study was held in the Dermatology department of Bahawal Victoria Hospital, Bahawalpur for one-year duration from March 2019 to March 2020. The total number of patients included in the study was 36. These patients were referred from various areas of the Punjab. All but one was men. Their ages ranged from 8 to 60 years. The duration of the disease ranged from 3 to 32 weeks. A skin biopsy of the most typical lesion was performed in each patient. The biopsy slide was stained with H&E dye and viewed under a microscope by one expert. Histopathological results were recorded according to the given criteria. Results: The diagnosis was confirmed by detecting amastigotes (LT bodies) in the preparations. They were detected in 11 out of 36 patients (30.55%). The other most significant finding found in all formulations was the presence of a mixed infiltration of inflammatory cells in the superficial dermis. Conclusion: It was found that the chances of capturing amastigote in biopsy specimens are not high. Hence, the presence of a dense, mixed infiltration of inflammatory cells in the superficial dermis should be treated as a diagnostic feature in the absence of LT bodies. Key words: Cutaneous leishmaniasis, histopathology, bodies LT

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