::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

DETERMINING THE LEVEL OF GLYCOSYLATED HEMOGLOBIN (HBA1C) IN PATIENTS AFTER ACUTE ISCHEMIC STROKE

AUTHORS:

Dr Saira Nasir, Dr Alina Sayyed, Dr Muhammad Adeel

ABSTRACT:

Concomitant risk factors associated with stroke are predictors of poor outcomes in stroke patients. Various risk factors, including high blood pressure, heart disease, diabetes (DM), smoking, alcohol consumption, stress, and depression, may account for 90% of the risk of stroke, as suggested by an international multicenter study. DM is considered to be an independent risk factor for ischemic stroke, with an estimated incidence of 21-44.4% in acute ischemic stroke patients. Several studies suggest poor functional outcomes in stroke patients with elevated blood glucose levels. Recent studies have shown poor results in patients with pre-diabetes and denovo diabetes in acute ischemic stroke. Therefore, based on the above findings, this study was designed to test the level of glycosylated hemoglobin (HbA1C) in patients after acute ischemic stroke. Methods: This study was planned at the Department of General Medicine Nishter Hospital Multan for one-year duration from August 2019 to August 2020. 200 people with stroke participated in this study. A CT scan was performed in all cases within 3 days of the onset of symptoms to confirm the diagnosis and determine the type of stroke (ischemic / hemorrhagic) and the size of the stroke (small, medium or major). Results and Conclusion: The data in this study suggest that hyperglycemia in non-diabetic patients after acute stroke is a stress response reflecting more severe neurological damage. Management of hyperglycemia in patients with and without diabetes mellitus is an important aspect of the emergency management of stroke. Further studies with larger samples and long-term outcome measures would be desirable to establish a definite association between in-hospital hyperglycemia and short- and long-term outcomes after stroke. Key words: glycosylated hemoglobin, HbA1C, acute ischemic stroke, etc.