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TITLE:

INCREASED RISK OF ACUTE HEPATITIS B IN ADULTS DIAGNOSED WITH DIABETES

AUTHORS:

Dr Muhammad Adeel, Dr Alina Sayyed, Dr Saira Nasir

ABSTRACT:

Background: The risk of acute hepatitis B in adult diabetic patients is unknown. We examined the link between diagnosed diabetes and acute hepatitis B. Methods: This study was held in the Medicine Unit-II of Jinnah Hospital Lahore for one-year duration from August 2019 to August 2020. Confirmed cases of acute hepatitis B were diagnosed with diabetes included in the study. Odds ratios (ORs) comparing acute hepatitis B among adults diagnosed with diabetes mellitus versus those without known diabetes were determined by multivariate logistic regression by age, sex, and race / ethnicity, and stratified by presence or absence of behavior risky for hepatitis B virus (HBV). Results: 865 cases of acute hepatitis B in people aged ≥23 years; 95 (11.0%) were diagnosed with diabetes. The incidence of diabetes mellitus in the comparative group was 9.1%. Among adults without hepatitis B risk behaviors and with a reported diabetes status, the OR for acute hepatitis B compared to non-diabetic and diabetic adults was 1.9 (95% confidence interval [CI] = 1.4; 2.6;); ORs for adults aged 23–59 and ≥ 60 years were 2.1 (95% CI = 1.6, 2.8) and 1.5 (95% = CI 0.9, 2.5), respectively. Conclusions: Diabetes mellitus was independently associated with an increased risk of acute hepatitis B in adults without HBV risk behavior. Key words: blood glucose monitoring, diabetes, hepatitis B, prophylaxis

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